Leicester Medical School
Department of Cancer Studies and Molecular Medicine

School of Medicine >> Cancer Studies and Molecular Medicine >> Cellular Interaction & Cell Signalling

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Cellular Interaction and Cell Signalling

“achieve greater understanding of molecular and cellular alterations that are key factors in cancer development and progression”.

Our aim is to translate the knowledge of molecular and cellular observations gained from in vitro model systems and in vivo analyses to the patient - clinical diagnosis, prognosis, therapy prediction and development of novel therapies.

 “From basic science to the clinic - a complete translational programme”.

Research is focused on four main cancers:

• B lymphocyte malignancies
• Urological
• Breast
• Skin

Each group comprises both scientists and clinicians, and are based in the Hodgkin Building (B lymphocyte malignancies, urology) and RKCSB (breast, skin). There are important interactions between these four groups as well as other members of Cancer Studies and Molecular Medicine, the Departments of Biochemistry, Genetics and Engineering, University of Leicester, clinicians of University Hospitals of Leicester NHS Trust, and National and International collaborations. Funding is from MRC, CRUK, AICR, British Urological Foundation, Breast Cancer Campaign, Medisearch, Hope Foundation.

Research approaches used by the section include:

• 2 and 3D in vitro model systems with primary cells and established cell lines
• Cell migration and 2 and 3D invasion assays
• Transfection (short term and stable), siRNA
• cDNA microarray, real time PCR
• CGH, SNP arrays, LOH/MSI analysis, SSCP, sequencing
• immunoblotting, immunoprecipitation, 2D gel electrophoresis
• immunofluorescence, confocal microscopy, immunohistochemistry, in situ hybridisation, image analysis

Senior Academic Staffing

B Lymphocyte Malignancies

• Prof MJ Dyer
• Dr EL Karran

Urology

• Prof K Mellon
• Mr L Griffiths
• Dr E Tulchinsky
• Dr M Kriajevska

Breast

• Prof RA Walker
• Dr JA Shaw
• Dr JH Pringle

Skin

• Dr G Saldanha
• Dr JH Pringle