Leicester Medical School
Department of Cardiovascular Sciences

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Dr Bob Norman

Deputy Head of Department, Senior Lecturer in Medical Biochemistry

B.Sc. (Biological Sciences), Leicester, 1978
Ph.D. (Biochemistry), Imperial College, 1981
Diploma of Imperial College, 1981
M.I.Biol 1975
C.Biol 1984
FHEA 2002

Contact details

Vascular Medicine Group,
Department of Cardiovascular Sciences,
University of Leicester,
Robert Kilpatrick Clinical Sciences Building,
Leicester Royal Infirmary,
Leicester,
LE2 7LX

Tel: 0116 2523178
Fax: 0116 2523273
Email: [email protected]

External positions

Editorial Adviser to the Biochemical Journal 1989-
Editorial Adviser to Cellular and Molecular Life Sciences (formerly Experimentia)1996-1999
Editor, Cellular and Molecular Life Sciences 2000-
Chair, Chaplaincy Council, Chaplaincy to the University of Leicester 2000-

Research interests

• Structure and regulation of the cardiac ATP-sensitive potassium channel
• Localization, structure and regulation of inward rectifier potassium channels
• Regulatory phosphorylation of the cardiac, L-type voltage-sensitive calcium channel
• Detrusor muscle instability/urinary incontinence

Publications in the last five years

Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG, Gaisano HY. Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation. J Biol Chem. 2006 Jul 14;281(28):19019-28.

Rainbow RD, Norman RI, Hudman D, Davies NW, Standen NB. Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K(ATP) channels during metabolic stress. J Mol Cell Cardiol. 2005 Oct;39(4):637-46.

Van Beever L, Poitry S, Faure C, Norman RI, Roatti A, Baertschi AJ. Pore loop-mutated rat KIR6.1 and KIR6.2 suppress KATP current in rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H850-9.

R D Rainbow, D Lodwick, D Hudman, N W Davies, R I Norman, N B Standen. SUR2A C-terminal fragments reduce KATP currents and ischaemic tolerance of rat cardiac myocytes. J. Physiol. 2004; 557:785-794.

Duflot S, Riera B, Fernádez-Veledo S, Casadó V, Norman RI, Casado FJ, Lluís C, Franco R, Pastor-Anglada M. ATP-sensitive K+ channels regulate the concentrative adenosine transporter CNT2 following activation by A1 adenosine receptors. Molecular and Cellular Biology 2004; 24:2710-2719

Rainbow RD, James M, Hudman D, Al Johi M, Singh H, Watson PJ, Ashmole I, Davies NW, Lodwick D, Norman RI. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. 2004. Biochem J. 379:173-181

England RC, Norman RI, Elliott RA. Direct inhibition of rat detrusor muscle contraction by erythromycin. Neurourol. Urodyn. 2004;23(3):273-9

Singh H, Hudman D, Lawrence CL, Rainbow RD, Lodwick D, Norman RI Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes 2003 Journal of Molecular and Cellular Cardiology 35(5): 445-459

Stonehouse A, Pringle JH, Conley EC, Norman RI, Stanfield PR, Brammar WJ. Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies. 2003 Journal of Molecular Neuroscience 20(2) 189-193

Books

Norman RI, Lodwick D. Medical Cell Biology Made Memorable. Churchill-Livingstone. 1999 Edinburgh 195pp. ISBN 0443 058156, ISBN-13 9780443058158

Norman RI, Lodwick D. Flesh and Bones of Medical Cell Biology. 2007 Mosby, Elsevier 124pp. ISBN 0723433674, ISBN-13 9780723433675

Last updated: 10/9/04
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