
			Leicester Medical School Department of Cardiovascular Sciences

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Dr Dave Lodwick

Lecturer in Molecular Biology

B.Sc Biochemistry with Chemistry, 1982, University of Southampton
Ph.D Molecular Genetics, 1989, University of Liverpool
FHEA, 2001

Contact details

Vascular Medicine Group,
Department of Cardiovascular Sciences,
University of Leicester,
Robert Kilpatrick Clinical Sciences Building,
Leicester Royal Infirmary,
Leicester,
LE2 7LX

Tel: 0116 252 3190 (Office)
Tel: 0116 252 3180 (Lab)
Fax: 0116 252 3273
Email: [email protected]

Research Interests

Molecular biology of ATP-sensitive potassium channels
Molecular genetics of Cardiovascular Disease

Cloning Vector Database

Membership of Learned Societies

The Society for General Microbiology 1986-
The Biochemical Society 1992-
The British Hypertension Society 1994-
The Medical Research Society 1994-
The International Society for Hypertension 1998-

Publications in the last 5 years

Y. Kang, B. Ng, Y. He, Y. Leung, H. Xie, D. Lodwick, RI. Norman, A. Tinker, RG. Tsushima, HY. Gaisano. Syntaxin-1a actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac KATP channel activation. JBC 2006;281:19019-19028.

SL.Hetherington, RK.Singh, D.Lodwick, JR.Thompson, AH.Goodall, NJ.Samani. A dimorphism in the P2RY1 receptor gene is associated with increased platelet activation response to ADP. ATVB 2005; 25:252-257.

R D Rainbow, D Lodwick, D Hudman, N W Davies, R I Norman, N B Standen. SUR2A C-terminal fragments reduce KATP currents and ischaemic tolerance of rat cardiac myocytes. J. Physiol. 2004; 557:785-794.

H.Kovalev, JM.Quayle, T.Kamishima, D.Lodwick. Molecular analysis of the sub-type selective inhibition of cloned KATP channels by PNU-37883A. 2004 Brit. J. Pharmacol. 141:867-873.

RD.Rainbow, M.James, D.Hudman, M.Al Johi, H.Singh, PJ.Watson, I.Ashmole, NW.Davies, D.Lodwick, RI.Norman. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with the pore-forming Kir6.0 subunits in KATP channels. 2004.Biochem. J. 379:173-181.

H.Singh, D.Hudman, CL.Lawrence, RD.Rainbow, D.Lodwick, RI.Norman. Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated cardiac myocytes. J. Mol. Cell. Cardiol. 35:445-459 (2003)

H.Mahadeva, G.Brooks, D.Lodwick, NW.Chong, NJ.Samani. ms1, a novel stress-responsive, muscle-specific gene that is up-regulated in the early stages of pressure overload-induced left ventricular hypertrophy. FEBS Lett. 521:100-104 (2002).

Review articles and editorials

D Lodwick. Receptor double-trouble in preeclampsia (News and Views). Nature Medicine 7:999-1000 (2001).

Books

R.I. Norman and D. Lodwick. Flesh and Bones of Medical Cell Biology. Mosby (2007) 124 pages.

R.I. Norman and D. Lodwick. Medical Cell Biology Made Memorable. Churchill Livingstone (1999) 195 pages.

Last updated: 20/6/07
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Leicester Medical School Department of Cardiovascular Sciences