Leicester Medical School
Department of Cardiovascular Sciences

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Professor Alison H Goodall

Professor of Thrombosis & Haemostasis
Chair of the Departmental Academic Committee

BSc (Biology), 1971, University of London
PhD (Biochemistry), 1979, University of London

Contact details

Cardiology Group,
Department of Cardiovascular Sciences,
University of Leicester,
Clinical Sciences Wing,
Glenfield General Hospital,
Leicester,
LE3 9QP

Tel: 0116 256 3026
Fax: 0116 287 5792
Email: [email protected]

External positions

President the British Society for Haemostasis & Thrombosis, 2001-2003
Editor-in-Chief, Clinical Science, 2001-2003
Member of the Committee of the British Atherosclerosis Society, 2001-2004
Editorial Board of Platelets, 1995-
Editorial Board of Clinical Science, 1995-2001 (Associate Editor for Cardiovascular Section, 2002-2006)

Research Interests

• Haemostatic mechanisms in atherothrombotic diseases
• Platelet biology
• Functional genomics of platelets and haemostatic factors
• Platelet transfusion

Thrombosis & Haemostasis Research Group

Membership of learned Societies

Medical Research Society 2001-
International Society on Thrombosis & Haemostasis 1999-
British Society for Haematology 1997-
British Atherosclerosis Society 1994-
British Society for Haemostasis & Thrombosis 1982-
Association of Clinical Biochemists 1997-2001
British Society for Immunology 1979-1995
British Society for Cell Biology 1976-1986
Biochemical Society 1975-1986; 2003-

Publications in the last 5 years

SL.Hetherington, RK.Singh, D.Lodwick, JR.Thompson, AH.Goodall, NJ.Samani. A dimorphism in the P2RY1 receptor gene is associated with increased platelet activation response to ADP. ATVB 2005; 25:252-257.

Goodall AH, Appleby JA. Flow cytometric analysis of platelet membrane glycoprotein expression and platelet activation. Methods in Molecular Biology 2004; 272: 225-253.

Webster SE, Payne DA, Jones CI, Hayes PD, Bell PRF, Goodall AH, Naylor AR. The Anti-platelet effect of Aspirin is Significantly Reduced following Administration of Heparin during Carotid Endarterectomy. Journal of Vascular Surgery 2004; 40: 463-468.

Payne DA, Jones CI, Hayes PD, Webster SE, Naylor AR, Goodall AH. Platelet inhibition by aspirin is reversed in patients during carotid surgery: a form of transient aspirin resistance? Thrombosis & Haemostasis 2004; 92: 89-96.

Payne DA, Jones CI, Hayes PD, Thompson MT, London NJ, Bell PR, Goodall AH, Naylor AR. The beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy. Circulation 2004; 109: 1476-1481.

Jones CI, Goodall AH. Differential effects of the iodinated contrast agents ioxaglate, iohexol and iodixanol on thrombus formation and fibrinolysis. Thrombosis Research 2003; 112: 65-71.

Hayes PD, Box H, Tull S, Bell PRF, Goodall A, Naylor AR. Patients' thromboembolic potential following carotid endarterectomy is related to the platelets' sensitivity to ADP. Journal of Vascular Surgery 2003; 38: 1226-1231.

Pickering W, Gray E, Goodall AH, Ran S, Thorpe PE, Barrowcliffe TW. Characterisation of the cell-surface procoagulant activity of T-Lymphoblastoid cell lines. Journal of Thrombosis & Haemostasis. 2003; 2: 1-9.

Moiseeva EP, Williams B, Goodall AH, Samani NJ. Galectin-1 interacts with b-1 submit of integrin. Biochemical & Biophysical Research Communications 2003; 310: 1010-1016.

Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ. White cell telomere length and risk of premature myocardial infarction. Arteriosclerosis Thrombosis Vascular Biology 2003; 23: 842-846.

Joutsi-Korhonen L, Smethurst PA, Rankin A, Gray E, IJsseldijk M, Onley CM, Watkins NA, Williamson LM, Goodall AH, de Groot PG, Farndale RW, Ouwehand WH. The low-frequency allele of the platelet collagen signalling receptor glycoprotein VI is associated with reduced functional responses and expression. Blood 2003; 101(11):4372-9.

Payne DA, Hayes PD, Jones CI, Belham P, Naylor AR, Goodall AH. Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action. Journal of Vascular Surgery 2002; 35(6):1204-9.

Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. Lancet 2001; 358(9280):472-3.

Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP. Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets. Journal of Vascular Research 2000; 37(6):437-42.

Li N, Hu H, Lindqvist M, Wikstrom-Jonsson E, Goodall AH, Hjemdahl P. Platelet-leukocyte cross talk in whole blood. Arteriosclerosis, Thrombosis & Vascular Biology 2000; 20(12):2702-8.

Thomas S, Metcalfe P, Goodall AH, Gray E. Monoclonal antibodies against platelet membrane glycoproteins IIb/IIIa and Ibalpha inhibit platelet dependent thrombin generation by different mechanisms. Thrombosis & Haemostasis 2000; 84(1):98-103.

Garner SF, Smethurst PA, Merieux Y, Aeby C, Smith G, Armour KL, Scott ML, Williamson LM, Metcalfe P, Goodall AH, Clark MR, Rigal D, Schawaller M, Ouwehand WH. A rapid one-stage whole-blood HPA-1a phenotyping assay using a recombinant monoclonal IgG1 anti-HPA-1a. British Journal of Haematology 2000; 108(2):440-7.

Review articles and editorials in the last 5 years

Goodall AH. The role of platelets and antiplatelet therapy in atherothrombotic disease. British Journal of Cardiology 2002; 9(suppl. 8): S2-S7

Last updated: 18/8/05
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