Research Interests

• Structure of proteins and the interactions between proteins and their ligands

• Nuclear magnetic resonance and analytical ultracentrifugation

McLaughlin, S.H, Sobott, F., Yao, Z.-P., Zhang, W., Nielsen, P.R., Grossmann, J.G., Laue, E.D., Robinson, C.V., & Jackson, S.E, The Co-Chaperone p23 Arrests the HSP90 ATPase Cycle to Trap Client Proteins. J. Mol Biol. 356, 746-758 (2006).

Nielsen, P.R, Nietlispach, D.,  Buscaino, A., Warner, R.J., Akhtar, A., Murzin, A.G., Murzinn, N.V., & Laue, E.D. Structure of the Chromo Barrel Domain from the MOF acetyl-transferase J. Biol. Chem. 280, 32326-32331 (2005).

Chattopadhyay, A., Jones, N.G., Nietlispach, D., Nielsen, P.R., Voorheis, H.P., Mott, H.R., & Carrington, M., Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2. J. Biol. Chem. 280, 7228-7235 (2005).

Nielsen, P.R., Callaghan, J., Murzin, A.G., Murzina, N.V., & Laue, E.D. Expression, purification, and biophysical studies of chromodomain proteins. Methods Enzymol. 376, 148-170 (2004).

Nielsen, P.R., Nietlispach, D. , Mott, H.R., Callaghan, J., Bannister, A., Kouzarides, T., Murzin, A.G., Murzina, N.V., & Laue, E.D. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature 416,103-107 (2002)