Publications (since 1994)

Elliott, P.R., Mohammed,S., Melrose, H.J. and Moody, P.C.E.M (2008) Expression, purification, crystallisation and preliminary X-ray analysis of a NADP-dependent Glyceraldehyde-3-phosphate Dehydrogenase from Helicobacter pylori. Acta Cyrstallographica Section F64, 727 -729

Elliott, P.R., Evans, D., Greenwood, J. and Moody, P.C.E.M (2008) Expression, purification, crystallisation and preliminary X-ray analysis of a NADP-dependent Glyceraldehyde-3-phosphate Dehydrogenase from Helicobacter pylori. Acta Cyrstallographica Section F64, 723-726

Chauhan, N., Basran, J., Efimov, I., Svistunenko, D., Seward, HE., Moody, PCE and Raven, EL. (2008) The role of serine 167 in human indoleamine 2,3-dioxygenase: a comparison with tryptophan 2, 3-dioxygenase. Biochemistry.47: 4671-4789

Badyal, SK., Metcalfe, CL., Basran, J., Efimov, I., Moody, PC E and Raven, EL (2008) Iron Oxidation state as a molecular trigger controlling active site structure in a Heme Peroxidase Biochemsitry.47: 4403-4409

SK Badayl, MG Joyce, KH Sharp, HE Seward, M Mewies, J Basran, IK Macdonald, PCE Moody & EL Raven (2006) Conformational mobility in the active site of a heme peroxidase J. Biol. Chem.281:34 24512-24520

Metcalfe, CL., Macdonald, IK., Murphy, EJ., Brown, KA., Raven, EL and Moody, PCEM. (2008) The tuberculosis prodrug isoniazid bound to activating peroxidases. J. Biol. Chem. 283: 6193-6200

Huang, W-C., Westlake, ACG., Marechal, J-D., Joyce, MG., Moody, PCEM and Roberts, GCK (2007) Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency J. Mol. Biol. 373 (3) 633-51

Efimov, I., Papadopulou, ND., McLean, KJ., Badyal, SK., Macdonald, IK., Munro, AW., Moody, PCE and Raven, EL. (2007) Biochemistry 46 (27): 8017-8023

IK MacDonald, SK Badayl, L Ghamsari, PCE Moody & EL Raven (2006) The Interaction of Ascorbate Peroxidase with Substrates: A Mechanistic and Structural Analysis Biochemistry (In press) (accepted 25/4/2006 Ref: bi0606849)

VE Pye, AP Tingey, RL Robson, & PCE Moody (2004) The Structure and Mechanism of Serine Acetyltransferase from Escherichia coli J. Biol. Chem. 279: 40729-40736

R Pierattelli, L Banci, NAJ Eady, J Bodiguel, JN Jones, PCE Moody, E Lloyd Raven, B Jamart-Grégoire, & KA Brown (2004) Enzyme-catalyzed Mechanism of Isoniazid Activation in Class I and Class III Peroxidases J. Biol. Chem. 279: 39000 – 39009

KH Sharp, PCE Moody, KA Brown & E. Lloyd Raven (2004) Crystal Structure of the Ascorbate Peroxidase-Salicylhydroxamic Acid Complex. Biochemistry, 43(27); 8644-8651.

H Khan, T Barna, RJ. Harris, NC. Bruce, I Barsukov, AW Munro, PCE. Moody, & NS Scrutton, (2004) Atomic Resolution Structures and Solution Behavior of Enzyme-Substrate Complexes of Enterobacter cloacae PB2 Pentaerythritol Tetranitrate Reductase: Multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation J. Biol. Chem., 279: 30563 – 30572

KH Sharp, PCE Moody & E Lloyd Raven, (2003) A new framework for understanding substrate binding and functional diversity in haem peroxidases Dalton Transactions, 22 4208-4215.

KH Sharp, M. Mewies, PCE Moody, E. Lloyd Raven, (2003) Crystal structure of the ascorbate peroxidase-ascorbate complex Nature Structural Biology 10, 303

H Khan, RJ. Harris, T Barna, DH. Craig, NC. Bruce, AW. Munro, Peter CE Moody, & NS Scrutton (2002) Kinetic and Structural Basis of Reactivity of Pentaerythritol Tetranitrate Reductase with NADPH, 2-Cyclohexenone, Nitroesters, and Nitroaromatic Explosives J. Biol. Chem., 277 21906 – 21912

T Barna, HL Messiha, C Petosa, NC. Bruce, NS. Scrutton, & PCE Moody (2002) Crystal Structure of Bacterial Morphinone Reductase and Properties of the C191A Mutant Enzyme. J. Biol. Chem., 277 30976 – 30983

RE Williams, DA Rathbone, PCE Moody, NS Scrutton, & NC Bruce, (2001). Degradation of explosives by nitrate ester reductases. Biochem. Soc. Symp. 68 143-153.

LY Lian , CS Allardyce , PCE Moody & GCK Roberts (2001) Structure and folding of glutathione S-transferase A1-1: structural transition and ligand interactions CHEM-BIOL INTERACT 133 (1-3): 13-16

DH Craig, T Barna, PCE Moody, NC Bruce, SK Chapman, AW Munro & NS Scrutton (2001) Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N1 atom and C2 carbonyl region of the active site flavin. Biochem. J. 359 315-323

TM Barna, H Khan, NC Bruce, I Barsukov, NS Scrutton, & PCE Moody (2001) Crystal structure of pentaerythritol tetranitrate reductase: "Flipped" binding geometries for steroid substrates in different redox states of the enzyme. J. Mol. Biol. 310 433-447

JEA Wibley, AE Pegg & PCE Moody (2000) Crystal Structure of the Human O6Alkylguanine-DNA Alkyltransferase. Nucl. Acids Res. 28 393-401

PE Verdemato, JA Brannigan, C Damblon, F Zuccotto, PCE Moody & LY Lian (2000) DNA-binding mechanism of the E. coli O6Alkylguanine-DNA Alkyltransferase Nucl. Acids Res. 28 3710-3718

VJ Hindson, PCE Moody AJ Rowe & WV Shaw. (2000) Serine acetyltransferase from Eschericia coli is a dimer of trimers J.Biol. Chem. 275 461-466

L Mazzarella, R D'Avino, G di Prisco, C Savino, L Vitagliano, PCE Moody & A Zagari. (1999) Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question. J. Mol. Biol. 287 897-906

GN Major, GB Notarianni, SJ Ross, MC Case JA Brannigan, DI Roper, PM Potter, TP Brent, PCE Moody (1999) Evidence for autoproteolysis of substrate-inactivated O-6-methylguanine-DNA methyltransferase following DNA repair British Journal of Cancer. 81 576

SM Cutfield, GJ Davies, G Murshudov, BF Anderson, PCE Moody, PA Sullivan, JF Cutfield (1999) The Structure of the Exo-b-(1,3)-Glucanase from Candida albicans in Native and Bound Forms: Relationship between a Pocket and Groove in Family 5 Glycosyl Hydrolases J. Mol. Biol. 294 771-783

N Chandra, KR Acharya & PCE Moody (1999) Analysis and characterization of data from twinned crystals. Acta Cryst. D55 1750-1758

PCE Moody, N Shikotra, CE French, NC Bruce & NS Scrutton (1998) Crystallization and preliminary diffraction studies of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2. Acta Cryst. D 54 675-677

SH Done, JA Brannigan, PCE Moody & RE Hubbard (1998) Ligand induced conformational changes in penicillin acylase. J.Mol. Biol 284 463-475

DH Craig PCE Moody, NC Bruce & NS Scrutton (1998) Reductive and oxidative half-reactions of morphinone reductase from Pseudomonas putida M10: a kinetic and thermodynamic analysis. Biochemistry 37 7598-7607

JA Rafferty, JEA Wibley, P Speers, I Hickson, GP Margison, PCE Moody, KT Douglas. (1997) The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modeling comparisons. BBA -Protein Structure And Molecular Enzymology. 1342 90-102

PCE Moody, N Shikotra, CE French, NC Bruce & NS Scrutton. (1997) Crystallisation and preliminary diffraction studies of morphinone reductase, a flavoprotein involved in the degradation of morphine alkaloids. Acta Cryst. D 53 619-621

NH Keep, M Barnes, I Barsukov, R Badii, L-Y Lian, AW Segal, PCE Moody & GCK Roberts (1997) A modulator of rho family G proteins, rhoGDI binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure 5 623-633

SM Dunn, PCE Moody, JA Downie & WV Shaw. (1996) Crystallization and preliminary diffraction studies of Nodl, a rhizobial O-acetyl-transferase involved in the host-specific nodulation of legume roots. Prot. Sci. 5 538-541

JEA Wibley, JH Mckie, K Embrey, DS Marks, KT Douglas, MH Moore & PCE Moody (1995) A homology model of the 3-dimensional structure of human O-6-alkylguanine-DNA alkyltransferase based on the crystal-structure of the C-terminal domain Of the Ada protein from Escherichia coli. Anti-Cancer Drug Design 10 75-95

JL Whittingham, S Chaudhuri, EJ Dodson, PCE Moody & Dodson GG (1995) X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol. Biochemistry 34 15553-15563

HJ Duggleby, SP Tolley, CP Hill, EJ Dodson, G Dodson, PCE Moody (1995) Penicillin acylase has a single amino-acid catalytic centre. Nature 373 264-268

SM Cutfield, EJ Dodson, BF Anderson, PCE Moody, CJ Marshall, PA Sullivan, JF Cutfield (1995) The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with 2 inhibitors. Structure 3 1261-1271

JA Brannigan, G Dodson, HJ Duggleby, PCE Moody, JL Smith, DR Tomchick, AG Murzin (1995) A protein catalytic framework with an N-terminal nucleophile is capable of self-Activation. Nature 378 416-419

MH Moore, JM Gulbis, EJ Dodson, B Demple, PCE Moody (1994) Crystal structure of a suicidal DNA-repair protein - The Ada O-6-methylguanine-DNA methyltransferase from Escherichia coli. EMBO J. 13 1495-1501

G Laughlan, AIH Murchie, DG Norman, MH Moore, PCE Moody, DMJ Lilley & B Luisi (1994) The high-resolution crystal structure of a parallel-stranded guanine tetraplex. Science 265 520-524

G Lange, SJ Lewis, GN Murshudov, GG Dodson, PCE Moody, JP Turkenburg, AN Barclay, RL Brady (1994) Crystal structure of an extracellular fragment of the rat Cd4 receptor-containing domain-omain-4. Structure 2 469-481

Last updated: 28 April 2008
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