University of Leicester Depatment of Biochemistry

		Department of Biochemistry


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Staff

Dr Mark D. Carr

D.Phil University of Oxford 1987
Royal Society Postdoctoral Fellow (European Science Exchange programme) and Max-Planck-Society Postdoctoral Fellow, Abteilung Biophysik, Max-Planck-Institut fur Medizinische Forschung, Heidelberg, Germany 1987-89.
MRC Postdoctoral Fellow, National Institute for Medical Research, London 1989-93
Group Leader, Laboratory of Molecular Structure, National Institute for Biological Standards and Control, London 1993-96
Lecturer in Structural Biology, Department of Biosciences, University of Kent 1997-2001
Reader in Biochemistry, NMR Centre 2001

Contact Details

Building	Henry Wellcome
Room	1.03
Email	[email protected]
Telephone	(+44) (0) 116 229 7075
Fax	(+44) (0) 116 229 7053
Address	Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

Research Interests

Functional Genomics of M. tuberculosis Complex Proteins Linked to Tuberculosis Pathogenesis and Protective Immunity.

Molecular Basis of the Control of Eukaryotic Gene Expression.

Structural Characterisation of Protein-Drug Interactions.

Recent Publications

Lightbody, K.L., Ilghari, D., Waters, L.C., Carey, G., Bailey, M.A., Williamson, R.A., Renshaw, P.S. and Carr, M.D. (2008) Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins. J. Biol. Chem. in press, advance online publication 21st April 2008, doi/10.1074/jbc.M800123200.

Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F.W., Taylor, R.J. and Carr, M.D. (2008) Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene 27, 585-595.

Waters, L.C., Veverka, V., Böhm, M., Schmedt, T., Choong, P.T., Muskett, F.W., Klempnauer, K.-H. and Carr, M.D. (2007) Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterisation of its interaction with eIF4A. Oncogene 26, 4941-4950.

Waters, L.C.,Yue, B., Veverka, V., Renshaw, P., Bramham, J., Matsuda, S., Frenkiel, T., Kelly, G., Muskett, F.W., Carr, M.D. and Heery, D.M. (2006) Structural diversity in p160/CREB-binding protein coactivator complexes J.Biol. Chem 281, 14787-14795

Waters, L.C., Böhm, M., Veverka, V., Muskett, F.W., Frenkiel, T.A., Kelly, G.P., Prescott, A., Dosanjh, N.S., Klempnauer, K.-H. and Carr, M.D. (2006) NMR assignment and secondary structure determination of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4. J. Biomol. NMR 36, S5, 18.

Veverka, V., Gregor, L., Crabbe, T., Bird, I., Taylor, R.J. and Carr, M.D. (2006) Letter to the Editor: NMR assignment of the mTOR domain responsible for rapamycin binding. J. Biomol. NMR 36, S5, 3.

Renshaw, P.S., Lightbody, K.L., Veverka, V., Muskett, F.W., Kelly, G., Frenkiel, T.A., Gordon, S.V., Hewinson, R.G., Burke, B., Norman, J., Williamson, R.A. and Carr, M.D. (2005) Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J. 24, 2491-2498.

Marei, A., Ghaemmaghami, A., Renshaw, P., Wiselka, M., Barer, M., Carr, M.D. and Ziegler-Heitbrock, L. (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6?CFP-10 complex. Int. Immunol. 17, 1439-1446.

Renshaw, P.S., Veverka, V., Kelly, G., Frenkiel, T.A., Williamson, R.A., Gordon, S.V., Hewinson, R.G. and Carr, M.D. (2004) Letter to the Editor: Sequence-specific assignment and secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-10 and ESAT-6: Towards an understanding of their role in tuberculosis pathogenesis. J. Biomol. NMR 30,225-226.

Lightbody, K.L., Renshaw, P.S., Collins, M.L., Wright, R.L., Hunt, D.M., Gordon, S.V., Hewinson, R.G., Buxton R.S., Williamson, R.A. and Carr, M.D. (2004) Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family; towards an understanding of the rules governing complex formation and thereby functional flexibility. FEMS Microbiol. Lett. 238, 255-262.

Carr, M.D., Bloemink, M.J., Dentten, E., Whelan, A.O., Gordon, S.V., Kelly, G., Frenkiel, T.A., Hewinson, R.G. and Williamson, R.A. (2003) Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal disease. J. Biol. Chem. 278, 43736-43743.

Jones, G., Howard, M., McIntosh, P., Williamson, R.A. and Carr, M.D. (2003) Letter to the Editor: Sequence-specific assignment of the B-Myb DNA-binding domain (B-MybR2R3) bound to a 16 base-pair DNA target site corresponding to a regulatory site from the tom-1 gene. J. Biomol. NMR 26, 375-376.

Renshaw, P.S., Panagiotidou, P., Whelan, A., Gordon, S.V., Hewinson, R.G., Williamson, R.A. and Carr, M.D. (2002) Conclusive evidence that the major T-cell antigens of the M. tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterisation of the structural properties of ESAT-6, CFP-10 and the ESAT-6-CFP-10 complex: implications for pathogenesis and virulence. J. Biol. Chem. 277, 21598-21603.

Last updated: 10 May 2006
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